RESUMO
Periodontal disease (PD) and obesity are characterized by a dysregulated inflammatory state. Both conditions trigger inflammatory and immune responses with an increase in proinflammatory cytokines such as Interleukin 6 (IL-6) and the release of inflammatory mediators such as C-reactive protein (CRP). Individuals with a high body mass index (BMI) present a chronic inflammatory state. The aim of the present study was to perform a systematic review of inflammatory markers (IL-6 and CRP) in obese patients with PD and their possible relationship by analyzing the levels of these markers. A digital literature search was performed in three databases-PubMed, SciElo and Medigraphic-through an advanced search for original articles, employing IL-6 and CRP in obese patients with PD, within a publication period from 2010 to 2021. PRISMA guidelines, the JADAD scale and a qualitative analysis of scientific evidence were performed using the Cochrane collaboration method and the RoB 2 assessment tool. Ten articles were included in this analysis with the variables recorded and associated with subjects with obesity and PD. Of the ten articles included, three analyzed IL-6 and CRP, four analyzed IL-6 and three analyzed CRP. In conclusion, and based on the available evidence, the aforementioned markers of inflammation demonstrate that there is a relationship between PD and obesity.
RESUMO
El propóleo es un material pegajoso de color oscuro obtenido de diversas plantas y mezclado con cera, deriva de las abejas quienes lo utilizan para proteger las colmenas. El objetivo del presente trabajo fue realizar una revisión bibliográfica acerca de las propiedades y usos del propóleo en odontología. Se realizó una búsqueda bibliográfica de reportes publicados de marzo del 2010 a marzo del 2020 en PubMed, Imbiomed, Medigraphic, SciELO y Google Scholar usando las palabras: propóleo, propiedades, usos. Se seleccionaron 39 artículos para la revisión. Las principales propiedades reportadas fueron: antimicrobiana, antiinflamatoria, inmunomodulador y cicatrizante. Los principales usos reportados abarcaron las siguientes áreas de la odontología: prevención de caries, endodoncia, periodoncia, prostodoncia y cirugía. En los últimos años, se ha puesto especial atención a las aplicaciones del propóleo ya que se ha demostrado su eficacia en distintas áreas de la odontología.
A Própolis é um material pegajoso de cor escura obtido de várias plantas e misturado com cera, derivado de abelhas que o utilizam para proteger suas colmeias. O objetivo deste estudo foi realizar uma revisão bibliográfica sobre as propriedades e usos da própolis na odontologia. Uma pesquisa bibliográfica de relatórios publicados de março de 2010 a março de 2020 foi realizada na PubMed, Imbiomed, Medigraphic, SciELO e Google Scholar usando as palavras: própolis, propriedades, usos. Trinta e nove artigos foram selecionados para revisão. As principais propriedades relatadas foram: antimicrobiano, anti-inflamatório, imunomodulador e cicatrização de feridas. Os principais usos relatados cobriram as seguintes áreas da odontologia: prevenção de cárie, endodontia, periodontia, prótese dentária e cirurgia. Nos últimos anos, uma atenção especial tem sido dada às aplicações do própolis, pois sua eficácia tem sido demonstrada em diferentes áreas da odontologia.
Propolis is a dark-colored sticky material obtained from various plants and mixed with wax, derived from bees who use it to protect their hives. The aim of the present work was to carry out a literature review on the properties and uses of propolis in dentistry. A bibliographic search of reports published from March 2010 to March 2020 was performed in PubMed, Imbiomed, Medigraphic, SciELO and Google Scholar using the words: propolis, properties, uses. Thirty-nine articles were selected for review. The main properties reported were: antimicrobial, anti-inflammatory, immunomodulatory, and wound healing. The main reported uses covered the following areas of dentistry: caries prevention, endodontics, periodontics, prosthodontics and surgery. In recent years, special attention has been given to the applications of propolis as its efficacy has been demonstrated in different areas of dentistry.
